Self-assembling of DNA Origami using Microfluidic Device



DNA origami tiles formed by folding circular DNA (M13mp18) with 7428 bp are utilized as functional building blocks on which various nanomaterials such as gold nanoparticles and SWCNTS are arranged. These DNA origami tiles are integrated with MEMS by directed self-assembly, to realize advanced NEMS (Nano Electro Mechanical Systems) such as high sensitivity biosensors and nanoscale waveguides based on Localized Surface Plasmon Resonance. In order to realize this approach, we propose new methodology using micro fluidic device to perform the directed self-assembly of the DNA origami tiles on a MEMS in solution.
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[Article]

  • O. Tabata, “A closer look at DNA nanotechnology : A bridge between nanomaterials and a nanosystem”, IEEE Nanotechnology Magazine, Vol.4, No.4, pp. 13-27, 2010.

[International Conference]

  • C. Huang, T. Saeki, M. Endo, H. Sugiyama, C.-H. Weng, G.-B. Lee, K. Sugano, T.   Tsuchiya, and O. Tabata, “Configurable Assembly of DNA origami on MEMS by   Microfluidic Device”,IEEE-NEMS2011, Kaohsiung, Taiwan, pp.203-206,2011.