Creating Gold Nanoparticle Dimers with nanogap by DNA Origami Sacrificial Method

To realize a single-molecule detection device for surface-enhanced Raman scattering measurements (SERS), a new approach which use DNA origami (DO) as a sacrificial nano-structure is proposed. In this approach, gold nanoparticles (AuNPs) are precisely self-assembled to form a dimer structure on opposite faces of a rectangular DO structure. AuNP dimers with about 1.5 nm gap were successfully fabricated on silicon chip by selective removing of DO using VUV irradiation and ultrapure water rinse.


  • Molecular detection by SERS measurement
  • Further enhancement by combining the features of DNA origami