Recent Tabata Lab’s publication in collaboration with Prof. Kamei at iCeMS was selected as “Inside Front Cover” on Advanced Healthcare Materials 2/2013.
Polymer-based microfabrication materials such as polydimethylsiloxane (PDMS) and photoresists (PRs) permit the creation of nano/microstructured substrates that enable the direct control of the cellular functions and phenotypes of human pluripotent stem cells (hPSCs), but their biocompatibility and effects on hPSCs are poorly understood.
Our group reveal that the tested materials preferentially direct hPSCs towards differentiation. The image depicts how PRs (yellow), PDMS (light blue) and glass (white) influence the capability of hPSC differentiation into various tissues, such as muscle, heart and neurons.
[Publication Information]
Ken-ichiro Kamei, Yoshikazu Hirai, Momoko Yoshioka, Yoshihide Makino, Qinghua Yuan, Minako Nakajima, Yong Chen and Osamu Tabata
Phenotypic and Transcriptional Modulation of Human Pluripotent Stem Cells Induced by Nano/Microfabrication Materials