On-chip size-separation of DNA origami nanostructures

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In this research, we explore on-chip size-separation process of DNA origami nanostructures and utilize it into rapid molecular assay. Also, a simulation tool for such system based on rigidbody dynamics is also being developed [Applications]

[Applications]

  • Computational simulation for on-chip size-separation of DNA and DNA origami nanostructure

  • On-chip molecular detection using DNA origami sensor

[Publications]

  • A Constrained Rigid Body Brownian Dynamics Simulation for On-Chip Size-Separation of Cross-linked DNA Origami Tiles, 28th International Microprocesses and Nanotechnology Conference, Toyama Japan, November 2015.
  • A Multibody Brownian Dynamics for Modeling Size-separation of dsDNA Fragment and DNA Origami Tiles in Anisotropic Nanosieving Array, NEMS 2016
  • On-Chip Separation of Triangular and Cylindrical DNA Origami Nanostructures Using Slanted Nanofilter Array 2016 Annual Meeting of the AES Electrophoresis Society, San Francisco CA