Radial mechanical property measurement of DNA origami nanotubes based on force-distance-based AFM

DNA origami nanotubes are utilized as structural platforms for the fabrication of various micro/nanosystems for drug delivery, optical or biological sensing, and even nanoscale robots. To investigate the effects of crossovers on the porosity and the radial mechanical properties of DNA origami nanotubes, we constructed the DNA origami nanotubes with varied crossover designs along the nanotube axis and measured their radial structural and mechanical properties based on force-distance-based AFM.


  • Bio/optical sensor
  • Drug delivery
  • Nanoelectronics


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  • Z. Ma et al., Direct Measurement of Transversely Isotropic DNA Nanotube by Force-Distance Curve-Based AFM, Micro & Nano Letters, 10 (10), 2015, pp.513–517.
  • Z. Ma et al., (forthcoming 2017), Tuning porosity and radial mechanical properties of DNA origami nanotubes via crossover design, Japanese Journal of Applied Physics.